PROTIA Allergy Q


Elevated total IgE, despite some well-known limitations, is often included as a diagnostic criterion for allergic diseases. There are many types of in vitro allergy diagnostic products for measuring total IgE concentration. Because multiple allergy detection kits, such as AlleryScreen® (Mediwiss Analytic GmbH and r-biopharma), Euroline (Euroimmun AG), Optigen® (Hitachi Chemical Diagnostics, Inc) and Polycheck® (Bio check GmbH), are tests of low cost, its uses in the clinic are growing rapidly today. However, there are few comparison studies for the total IgE level between various allergy detection kits and ImmunoCAP, a well-known quantitative allergy diagnostic kit. The aim of this study is to compare the serum total IgE concentration of Protia Allergy-Q, a multiple allergy detection kits, with ImmunoCAP and to evaluate the clinical usability of Protia Allergy-Q.


392 patients who visited the Korean Medicine Hospital, Kyung Hee Medical Center were enrolled in this study. Informed consent was obtained from all patients. After collecting five millilitres of whole blood in a vacuum tube, the serum was separated by centrifugation at 3000 rpm for 5 min, aliquoted into several round-bottom tubes, and frozen at -80 ° C until use. ImmunoCAP was tested by Green Cross Laboratories (Yongin-si, Korea) and Protia Allergy-Q was made by us. The correlation between the two trials was analyzed using Passing-Bablok regression analysis.


The average total IgE of 392 sera measured by ImmunoCAP and Protia Allergy-Q was 167.1 and 149.4 km / l, respectively. Passing-Bablok regression analysis showed that ImmunoCAP and Protia Allergy-Q exhibited a near-perfect correlation (intercept, 5.6676 [95% confidence interval {CI} 4.3282, 6.9388] and slope, 0, 8676 [95% CI: 0.8211, 0.9107]).


Portia Allergy-Q, a multiple allergy screening kits, is a low-cost screening test for patients with suspected allergies. Provides 60 kinds of specific IgE levels, but also total IgE levels. Although it is a semi-quantitative assay, the total IgE concentration analyzed by Allergy-Q is almost equal to that of ImmunoCAP. Therefore, it can be a very convenient tool to measure not only specific IgE but also total IgE concentration.

Related Post

Leave a Reply

Your email address will not be published. Required fields are marked *